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16 More recently, early-phase studies of a novel drug class in clinical development, the pyruvate kinase activators, have shown potential for raising hemoglobin level and reducing sickling and hemolysis in individuals with SCD

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Zinc is necessary for the optimal function of key immune cells, including, neutrophils, macrophages, natural killer (NK) cells, and lymphocytes, all of which contribute to a robust and responsive immune system [5]

For more significant changes like improved skin brightness or enhanced immune response, several months of regular use may be necessary