Its incidence is 1 to 5 cases per million person-years, and common causative drugs are antibiotics, antimycotics, hydroxychloroquine, and diltiazem
Macrophages of the vascular wall can collect iron, and iron overload in turn causes macrophages to transition to an anti-inflammatory phenotype, which leads to inflammation, oxidative stress, and increased plaque formation
Cell cultures were cultivated in usual conditions on 37C and 5% CO2
For in vitro experiments, embryonic rat cardiomyocytes (H9c2 cells) exposed to hypoxia-reoxygenation (HR) showed a time-dependent increase in gp91 phox (a marker for ROS production by NADPH oxidases), caspase-3 (a key mediator of apoptosis) expression, and a decrease in the glutathione redox ratio
Une mta-analyse de 9 essais contrls randomiss confirme que les effets sur la composition corporelle sont statistiquement significatifs mais ncessitent d'tre associs une alimentation adapte et l'exercice physique pour obtenir des rsultats optimaux
This mechanism remains less well characterized than the two previous ones and requires further independent validation
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