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Probing position N108, we found that incorporation of any other amino acid resulted in a substantially reduced formation of cyanidin ( 8 ) suggesting that the hydrogen-bond interaction of the asparagine to the flavonoid substrate is critical for dehydratase activity, while GSH-transferase activity was comparatively less affected for N108 variants comprising an alanine, histidine, tyrosine or tryptophan (Fig

Ann Intern Med 104:399 Wootton FT, Lee WM (1990) Acetaminophen hepatotoxicity in the alcoholic

Nutritional status, enzyme activity and clinical context are all important considerations when selecting the most appropriate form of folate

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Advances in Ophthalmology Practice and Research, 4 , 173181