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However, these findings have not been observed in human studies, and the clinical relevance remains uncertain

The responsible framing is that the barrier and the immune system are intimately linked, that permeability is a plausible and partly validated contributor, and that the full causal picture is still being worked out

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High Grade Dysplasia High-grade dysplasia ( Image 5, Figure 7 ) is thought to be the stage that occurs before esophageal cancer

The correct C rating depends on the model and what you actually expect from it