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Genetic investigations have revealed that knockdown of MFN2 in mice disrupts mitochondria-ER contacts, causing a decline in membrane potential and an accumulation of ROS, which ultimately triggers follicular developmental arrest and an elevated apoptosis rate [279]

This reaction is the rate-limiting step in GSH synthesis

3 Results 3.1 Uptake of acetaminophen To evaluate the uptake of acetaminophen during the 3 h of incubation, samples of root cells and growth medium were taken right after 0, 1, 2, and 3 h after the addition of acetaminophen

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