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CX3CL1 promotes cell sensitivity to ferroptosis and is associated with the tumor microenvironment in clear cell renal cell carcinoma

03 Potential for lower doses Using these medications in combination might allow for lower doses of each, potentially reducing side effects while maintaining efficacy

The higher sensitivity of MDA-T32 and MDA-T68 cells to RSL3 treatment may be due to the fact that RSL3 was originally selected from the chemical screen that showed synthetic lethality against RAS mutation and active TERT expressing cells 26

This interaction results in the formation of a complex that suppresses the ubiquitination and subsequent degradation of the transcription factor BACH1