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Subsequently, colorectal cancer cells release TGF-1 into the tumor microenvironment, where it activates the mothers against decapentaplegic homolog 3 (SMAD3) pathway in memory CD8 + T cells, ultimately impairing their antitumor activity (45)

Losing excess weight and cutting down accumulated body fat is not only relevant for aesthetic body shape but being overweight and obese accounts for several cardiovascular and cardiometabolic disorders such as hypertension, coronary artery disease, diabetes mellitus, etc

doi: 10.3390/molecules25184320

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Such deficiencies may play a role in the etiology of diseases