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To confirm that interface IV is essential for c-MET activation, we introduced Y673A mutation into HGF to disrupt this interface, and showed that HGF Y673 mutant has a great deficiency in binding to c-MET as well as promoting c-MET activation (Fig

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This can occur due to various factors including: Stomach stretching over time, allowing increased food intake Metabolic adaptation , where the body adjusts to lower calorie intake Behavioural factors , such as return to previous eating patterns Hormonal changes that may affect appetite regulation For patients experiencing inadequate weight loss or significant weight regain after gastric sleeve, GLP-1 receptor agonists may provide additional support

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