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GLP-1 receptor agonists bind to GLP-1 receptors on pancreatic beta cells, triggering glucose-dependent insulin secretion

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It interacts with the nitric oxide system through the VEGFR2-Akt-eNOS axis and the Src-caveolin-1-eNOS pathway [PMID: 40789979]

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In-vitro fibroblast studies indicate that GHK-Cu upregulates transcription of collagen and elastin genes and supplies copper as a cofactor for lysyl oxidase, the enzyme that cross-links these matrix proteins