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The freckles arising on the nose and cheeks of young children following sun exposure are due to localised increase in melanin production from normal melanocytes
This imbalance might cause LPS to be increasingly produced and enter the bloodstream, triggering widespread inflammation through IL-10, disruptions in the HPA axis, and a reduction in cortisol levels, another factor linked with ME/CFS [79, 80]
10.1136/bjsports-2015-095906 62
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