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ERR agonism (SLU-PP-332): investigated as a synthetic pan-ERR (estrogen-related receptor) agonist studied for its effects on mitochondrial gene expression and oxidative metabolism, a mechanism central to exercise-mimetic research

Several later papers involved authors with commercial development interests

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Published clinical trials used continuous daily administration for 12-24 weeks without scheduled breaks, establishing this as a viable approach with maintained safety throughout the treatment period