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Yes, the AOD-9604 half life can be significantly influenced by the route of administration

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Nature 545 , 294295 (2017)

10.1073/pnas.96.22.12905 142

its strongest evidence base is in cardiac muscle, skeletal muscle, and skin wound healing models The combination is studied to investigate whether the two pathways exhibit additive or synergistic effects across tissue repair endpoints a question that would be difficult to study with either compound alone

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