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(2024, CNS Neuroscience & Therapeutics ) confirmed ARA-290 provided neuroprotective effects in a mouse MCAO (middle cerebral artery occlusion) model comparable to full-length EPO, significantly reducing neuronal apoptosis and inflammatory cytokines, confirmed to act via CR without stimulating erythropoiesis Blood-brain barrier (BBB) penetration confirmed in pre-clinical studies

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In addition, the beneficial bacterium up-regulated the expression of several defense genes encoding PR-10a, the antioxidative monodehydroascorbate reductase enzyme and two GSTs (Maketon et al., Pseudomonas putida strongly increased the drought tolerance of chickpea

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[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Widjaja G et al