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It is because tissue repair is multifactorial

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Benderska N, Ivanovska J, Rau TT, Schulze-Luehrmann J, Mohan S, Chakilam S, Gandesiri M, Ziesche E, Fischer T, Soder S, Agaimy A, Distel L, Sticht H, Mahadevan V, Schneider-Stock R (2014) DAPK-HSF1 interaction as a positive-feedback mechanism stimulating TNF-induced apoptosis in colorectal cancer cells