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Biol Trace Elem Res (2017) 179:3844

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In addition, the BBB is involved in completing the regulation of neurotransmitter distribution in the CNS by physically separating central and peripheral nerves

But even if you and your veterinarian are able to get the underlying problem under control, the symptoms may not completely resolve because if left untreated, cobalamin deficiency causes vomiting, diarrhea, and weight loss

An overview on glycation: molecular mechanisms, impact on proteins, pathogenesis, and Inhibition