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These observations support a model of APR-246 activity in which cell death is induced via various mechanisms in both p53-dependent and p53-independent manners

Curr Opin Pharmacol 7:3559 Samuni Y, Goldstein S, Dean OM, Berk M (2013) The chemistry and biological activities of N -acetylcysteine

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Incorporated as selenocysteine, it provides the catalytic power needed for efficient peroxide reduction, far surpassing what cysteine-based variants can achieve

The downside to nasal administration is rapid metabolism of the peptide, which may necessitate multiple doses throughout the day

References Amin NH, Kumar NS, Schickendantz MS