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The mitogen-activated protein kinase (MAPK) and nuclear factor-B (NF-B) pathways have both been associated in adrenal hormonal imbalance-associated oxidative stress

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The study enrolled over 300 participants across the U.S., Europe, the U.K., and Australia, who were randomized to receive either larsucosterol (30 mg or 90 mg) or placebo, with all groups receiving standard supportive care [118]