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In addition, new drugs such as tirzepatide have come onto the market, expanding the therapeutic options for successful treatment of T2DM and obesity

[ref][ref] HNMT gene: Histamine N-methyltransferase (HMNT) is the enzyme that regulates histamine in the body via converting it from histamine into N-methylhistamine, which can then be eliminated from the body

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However, the complete immunological mechanisms of sensitisation for isocyanate and other low-molecular-weight sensitisers are not completely understood, as exposure can result in multiple hypersensitivity pathways

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