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(Berl.) 95 , 323333

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2014, pp

The importance of cancer cell metabolism and the limitations of conventional cancer therapies (e.g., resistance to chemotherapy or radiotherapy) have prompted the development of strategies aimed at targeting this biological process 2

This phenomenon can be attributed to the upregulation of FABP4 by Notch1, which subsequently enhances tumor growth and angiogenesis in ovarian tumor xenografts (91)

Following discovery of a sparse number of occurrences of progressive multifocal leukoencephalopathy (PML) in those taking a FAE, median duration of FAE therapy to PML symptom onset or appearance of first PML brain lesion was 31 months (range 6110), with median duration of lymphocytopenia to PML symptoms being 23 months (range 672)