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MDR1, also known as permeability glycoprotein ( P-gp ), is a transmembrane transport protein that recognizes and controls drug efflux from tumor tissues and eventually promotes drug resistance in breast cancer by altering drug distribution in tumors 52

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Best Melasma Treatment Products to Use at Home (2025 Edition) Recommended Actives and Brands Topicals: Azelaic acid, niacinamide, licorice extract, arbutin Sunscreens: Mineral-based with iron oxides (e.g., ISDIN, EltaMD, SkinCeuticals) Serums: Containing tranexamic acid (e.g., SkinCeuticals Discoloration Defense) Patch Testing and Usage Consistency Introduce new products gradually