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5-Amino-1MQ functions as a competitive inhibitor at the nicotinamide substrate site of NNMT, with an IC50 of 1.2 M against human NNMT

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A similar study focusing on arginine-lysine MODIC, GODIC, and DOGDIC crosslinks showed that, differently from glucosepane, DOGDIC seems to not inhibit collagen organization through spatial interactions but rather facilitate ordered collagen packing (Nash et al ., 2021)

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