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Receiver operating characteristic curve analysis demonstrated the best diagnostic accuracy at an IGF-1 cutoff of 1.493 SD, with 0.685 sensitivity, 0.417 specificity, 0.25 positive and 0.823 negative predictive values, and 0.517 area under the curve
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The combined effect can lead to a more pronounced increase in GH levels
Furthermore, the level of a specific diacylglycerol, DG (14:1(9Z)/22:1(13Z)/0:0), which was downregulated in the HFD group, was further reduced by Retatrutide treatment
92: 761-794, viii
The human enzyme has been shown to possess an additional sorting signal that allows the enzyme to be segregated in the trans -Golgi network and then to the apical membrane (Wessels et al., 1990)
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