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PLoS One 8, e66557, doi: 10.1371/journal.pone.0066557 (2013)

In many cases, it is essential to accurately control the time at which the data are taken or it invariably will introduce error into the analysis

395 Reducing the levels of these factors in aged plasma partially mitigates their detrimental effects on young brains

Geoffrey Littlejohn, adjunct clinical professor at Monash University, said the concept needed clarification in a well-conducted double-blind placebo-controlled study

In practice, if a therapy is considered, success should be defined with measurable endpointssleep quality, function, waist circumference/body composition (when appropriate), and metabolic markersrather than vague claims alone

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