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102 In vitro treatment with 1-h H 2 O 2 demonstrated that the catalytic activity of POLG was reduced to 50% of the original level with significantly lower DNA binding efficiency

Lee HK, Vaporciyan AA, Cox JD, Tucker SL, Putnam JB Jr, Ajani JA, Liao Z, Swisher SG , Roth JA, Smythe WR, Walsh GL, Mohan R, Liu HH, Mooring D, Komaki R

47,131,133,139149 These inhibitors may target upstream signaling events, such as potassium efflux, 81 mitochondrial dysfunction, 150 or lysosomal destabilization, 151,152 all critical for NLRP3 activation

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Lippincott, Philadelphia Choi I-Y, Lee S, Denney DR, Lynch SG (2011) Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T