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Hyaluronic acid (HA) is another popular biomaterial most commonly used post-operatively, particularly in the form of a hydrogel, and can be combined with both natural molecules as well as synthetic polymers (Markowska et al., 2023)

Lin SK, Tsai SM, Huang JC, Lee SC, Wu SH, Wu SH, et al

Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts

N-acetylcysteine (NAC) and GSH, with antioxidant properties, can scavenge ROS during ischemiareperfusion injury

Their ability to address multiple pathological mechanisms simultaneously makes them valuable candidates for improving long-term outcomes

Coen 2015)