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The concentrations of IL-17 and TNF-, two important proinflammatory cytokines, were prominently increased, whereas those of certain chemokines, such as RANTES, MIP-1, MIP-1, and MCP-1, were markedly decreased in MS-affected patients compared with those in healthy controls

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At 0.2mmol/l CuSO 4 , no significant differences were observed, but higher concentrations (0.41.4.2mmol/l) significantly increased toxicity in HepG2 ATP7B-KO cells (Fig