Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver
Loading phase (4-6 weeks): Typical loading doses range from 2 to 2.5 mg administered twice weekly, totaling 4-5 mg per week
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It can result from elevated estrogen production (excess adipose aromatase activity), reduced estrogen clearance (impaired hepatic Phase I or Phase II metabolism), low SHBG (leaving more biologically active free estrogen), xenoestrogen exposure, or progesterone insufficiency
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The theoretical risk of uncontrolled angiogenesis has been raised in mechanistic discussions and has not been adequately ruled out in humans (but dont take this as any sort of positive evidence that BPC-157 causes cancer0
