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Linked to serious side effects including anaphylaxis & kidney damage

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Central appetite suppression: Amylin crosses blood-brain barrier Activates area postrema (brainstem) Also acts on nucleus accumbens Direct satiety signaling Reduces desire to eat Different brain pathways than GLP-1 3

ZarkovicNZarkovicKMilkovicLAndrisicLBorovicSWaegGet alRevealing 4-Hydroxynonenal-Histidine adducts as qualitative and quantitative biomarker of oxidative stress, lipid peroxidation and oxidative homeostasis

The native crystal structure of CH is altered by synthesized chemical substances, which disrupt the hydrogen bonds that connect the molecules, increasing chitosan permeability and broadening its applications (Ma et al., 2009