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Structure and dynamics of the active Gs-coupled human secretin receptor

Walker et al

Although oxidative stress was defined originally as a balance between oxidants and antioxidants systems, an equilibrium among antioxidant strategies is needed to avoid the generation of oxidants and ROS ( SUPEROXIDE, HYDROGEN PEROXIDE, AND PEROXYNITRITE GENERATION Despite the fact that superoxide can be generated in extramitochondrial reactions, in most cell types mitochondria appear as the main source of superoxide generation

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It may appear as an orthostatic intolerance, i.e., an inability to adapt hemodynamic parameters (cardiac frequency, blood pressure) to a vertical position, revealing a defective baroreflex-cardiovagal function