Stokes PR, Egerton A, Watson B, Reid A, Breen G, Lingford-Hughes A, et al
(2)Fmoc-Leu-Val- (2) Preparation of Fmoc-Leu-Val-resin: (1)Fmoc-Val-1050530105010603DMF3DMF2DMFFmoc-Leu-OHDIEATBTU/HOBtHBTU/HOBtBOP/HOBt105010603DMF3DMF2Fmoc-Leu-Val- In the Fmoc-Val-resin of step (1), add decapping reagent 1050 and react for 530 minutes, drain with vacuum pump, add decapping reagent again 1050 and react for 1060 minutes, decapture, use iso Wash 3 times with propanol, 3 times with DMF, 2 times with distilled DMF, add the mixture of Fmoc-Leu-OH, DIEA, TBTU/HOBt or HBTU/HOBt or BOP/HOBt dissolved in DMF, 10-50 React at for 10-60 minutes, dry with a vacuum pump, wash with isopropanol for 3 times, DMF for 3 times, DMF that has been re-distilled for 2 times, and dry to obtain Fmoc-Leu-Val-resin
1 H-fMRS data acquisition The data were collected at 3 Tesla on a General Electric Discovery MR750 magnetic resonance scanner equipped with a 32-channel receive-only head coil at the NIHR Kings Clinical Research Facility, UK
Evidence on safety and optimal dosing schedules is limited
Vitamin B12 is key for nerve health
Pathol Int 62:463470
