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As for vascular growth, which is highly correlated with tumor development, bilirubin inhibits ERK activity in damaged blood vessels, and because ERK activation is associated with the mitogenic stimulation-induced cyclin D1 expression (102, 103), the reduction of ERK activity caused by bilirubin may be responsible for the down-regulation of cyclinD1 by bilirubin after arterial injury

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Levenson JM, Schroeter S, Carroll JC, Cullen V, Asp E, Proschitsky M, Chung CH-Y, Gilead S, Nadeem M, Dodiya HB et al (2016) NPT088 reduces both amyloid- and tau pathologies in transgenic mice