Six LOX subtypes are expressed in humans [300]: ALOX5, ALOX12, ALOX12B, ALOX15, ALOX15B, and ALOXE3
Fakayode et al
It acts as a chemoattractant, recruiting immune cells like macrophages and mast cells to the site of investigation
Additionally, adipose tissue macrophages secrete miR-140-5p in extracellular vesicles, which targets SLC7A11 in cardiomyocytes, inhibiting ferroptosis induced by reduced glutathione synthesis, presenting a new therapeutic strategy for obesity-induced cardiac injury [117]
Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury
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