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Gene expression analyses show that GHK influences genes relevant to nerve growth factors, antioxidant enzymes in the brain, and anti-inflammatory signaling pathways (Pickart et al., 2017)

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doi:10.1038/nature08980

Subsequent studies have shown that erastin-induced cell death in the fibrosarcoma cell line HT1080 and the lung cancer cell line Calu-1 relies on iron accumulation, consequent oxidative damage through the activation of the Fenton reaction, and inhibition of system xc - [4]