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PLoS Med 17, e1003084 (2020)

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Acetaminophen is metabolized in the liver, where about 90 percent is converted into harmless compounds that are then excreted in urine

Of these, 72 (59%) had rheumatologic conditions including inflammatory arthritis, sarcoidosis, vasculitis, spondyloarthritis, Behet disease, myositis, PMR, systemic lupus erythematosus, rheumatic fever, and Sjgren syndrome

Substrates for this reaction include acetaminophen, morphine, chloramphenicol, furosemide, sulfisoxazole, and valproic acid

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