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Effect of study bias, publication bias, and small-study effects In all analyses, the pooled estimated SMDs for the subgroups of studies deemed to have low bias was within the 95% CI of the overall (Table 4), suggesting the impact of studies with higher bias was small

This combination downregulates Nrf2 in the cytoplasm while upregulating its nuclear expression, enhancing nuclear translocation and increasing HO-1 mRNA and protein expression

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