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Correa-Rodrguez M, Luis Gmez-Urquiza J, Medina-Martnez I, Gonzlez-Jimnez E, Schmidt-Riovalle J, Rueda-Medina B

255 UPS regulation of cell cycle progression and metabolic reprogramming The UPS tightly controls cell cycle regulators, such as cyclins and cyclin-dependent kinase (CDK) inhibitors, whose dysregulation is common in cancer

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They often result from a combination of genetic, environmental, and lifestyle factors, and share common pathological mechanisms, such as chronic oxidative stress, excitotoxicity, neuroinflammation, and mitochondrial dysfunction