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This leads to severe oxidative stress, lipid peroxidation, and catastrophic damage to cellular membranes and mitochondrial DNA, triggering systemic inflammation

1 Introduction Pyrroloquinoline-quinone (PQQ) was discovered as a bacterial coenzyme for dehydrogenase (Hauge, 1964), and its structure was later determined by derivatized crystallography (Salisbury et al., 1979)

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6,11 In terms of specific immune-related adverse events, CTLA-4 inhibitors are often associated with gastrointestinal adverse events, whereas PD-1/PD-L1 inhibitors are more frequently associated with thyroid-related adverse events and pneumonitis

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Hyperthyroidism (primary)