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The CagriSema amylin+GLP-1 combination achieves effects comparable to Retatrutide monotherapy, but Retatrutide has a stronger standalone effect (24 % in Phase 2)

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The evidence is encouraging

Furthermore, flies harboring a global null mutation of Ube3a exhibited significant circadian deficits, supporting the notion that Ube3a is an integral component of the Drosophila circadian clock (Wu et al., 2008)