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PHH/PMH have some disadvantages including difficulty in culture, phenotype change at an early stage, metabolic enzymes easy inactivation, and individual differences between donors, which limit their practicability and reliability as an in vitro model

Further research is needed to investigate GSH dynamics longitudinally, validate these observations in independent cohorts, explore the therapeutic potential of antioxidant interventions, and confirm these findings in multicenter studies

Curr Protein Pept Sci

This method ensures that 100% of the nutrients are available for the body to use, which can be particularly beneficial for individuals with digestive issues or those recovering from illness

Similarly, oral medications may be more practical for those who travel frequently, since they dont require refrigeration and can be stored at room temperature

Antioxidant enzymes such as SOD, GSH, CAT and HO1, whose upregulation augments the capacity to counteract ROS