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In hyperuricemia, uric acid is supersaturated in urine and forms uric acid crystals, which are transported to lysosomes by the endocytosis of renal tubular epithelial cells, destroying the lysosomal membrane and causing lysosomal rupture, in turn, resulting in renal inflammation 20

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Finally, based on recent studies on the interaction of ACE2 and the SARS-CoV-2 virion, it is possible that the PDZ-based complex of ACE2, BAT o 1 and -arrestin 77 may be mediated by NHERF1 to enable clathrin-assisted internalization into endosomes 78

51 Recent studies exploring in vitro haptenation 10 and depletion of GSH by potent skin sensitizer 2,4-dinitro-1-chlorobenzene (DNCB) in HaCaT cells 52 showed that both events peak at approximately 2 h post treatment