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Oral delivery of macromolecular drugs: where we are after almost 100 years of attempts

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Initial assessment of rats that underwent two ligations of the left colic artery and vein for 15 min (IC rats) Regular course (saline bath, control): Frequently, once major vessels were obstructed, the alternative arcade only partially appeared in the blood-deprived colon segment (Figures 2, 3, 5 and 6)

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