All of these factors can contribute to poor production of glutathione (or of the enzymes that help glutathione to do its work), and many also deplete the GSH that the cells produce (by converting it into GSSG)
Parkinsons Progression Markers Initiative
But under heavy demand stress, lots of sun, poor diet, aging your stores can run low
Fu S C, Cheuk Y C, Chiu W Y V, et al
in fact, coffee consumption 2 cups/day protects against the progression of almost all forms of liver disease with incremental beneficial effects up to 6 cups/day
Li HN, Zimmerman M, Milledge GZ, Hou XL, Cheng J, Wang ZH, Li PA (2017a) Water-soluble coenzyme Q10 reduces rotenone-induced mitochondrial fission