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ROS levels allow the activation of pro-tumorigenic signaling pathways without induced cell death [12, 17]

THE HYPOTHALAMO-PITUITARY INTERFACE The hypothalamus and pituitary serve as the bodys primary interface between the nervous system and the endocrine system

However, oxidative stress induces phosphorylation and downregulates IB, an apoptosis antagonist, but the activated NF-B promotes cell proliferation and produces cancers [55,56,57,58]

Addressing these priorities will be critical for advancing HDT from preclinical promise to clinical reality, and (4) developing more robust and physiologically relevant in vitro assays and in vivo models that better recapitulate the complex hostpathogen interactions and immune responses observed in human TB