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In vivo, such nitrosylation events occur continuously under conditions of inflammation and oxidative stress, even though the resulting adducts are typically short-lived and rapidly converted into downstream oxidation products

When you swallow a B12 pill, several steps have to work for it to be absorbed: stomach acid and the enzyme pepsin must release B12 from food or the supplement, the stomach must secrete a protein called intrinsic factor that binds to B12, and the B12-intrinsic factor complex must reach the ileum (the end of the small intestine) where it is finally absorbed

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Fukai T, Ushio-Fukai M (2011) Superoxide dismutases: role in redox signaling, vascular function, and diseases