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Targeted therapeutics The dynamic interplay between lactate metabolism and lactylation-driven epigenetic reprogramming has emerged as a hallmark of diverse pathological processes, such as cancer, inflammatory disorders, and metabolic syndromes

IGF-1 availability is tightly regulated by the so-called insulin-like growth factor binding proteins (IGFBPs), which may act by increasing IGF-1 half-life, from minutes to hours (most commonly by forming a tertiary complex with Acid-Labile Subunit and IGFBP3), however blocking its binding to the insulin-like growth factor 1 receptor (IGF-1R) [9395]

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