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Choline Choline is used to synthesize acetylcholine, a neurotransmitter involved in muscle control and numerous functions of the nervous system

It is the same logic as a loading phase followed by a maintenance phase in many research protocols: front-load to establish, then hold with less

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Those who follow a vegetarian or vegan diet may have trouble getting enough B12 from food alone

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For severe deficiency, the AAFP recommends loading doses typically daily or every other day for one to two weeks followed by monthly maintenance injections