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Instead of asking 'why not stack them,' the question becomes 'what specific outcome justifies adding a second compound with incomplete human safety data?' For research exploring maximal metabolic intervention where single-agent tirzepatide has plateaued, the stack may be defensible

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Experienced researchers tend to choose based on the specific experimental question

Advances in Experimental Medicine and Biology, 681, 107-116

The memory seems uncalled for and may recur, intruding on other thoughts