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To accommodate the tumors growth, there is an upregulation in the expression of angiogenic factors like vascular endothelial growth factor (VEGF), leading to the abnormal proliferation and expansion of tumor vasculature, a hallmark of high-grade gliomas [145]

Recurrent loss of NFE2L2 Exon 2 is a mechanism for Nrf2 pathway activation in human cancers

N., Majmudar, G., et al

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10.1038/s41380-021-01160-8 70

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