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During APAP overdose, damaged hepatocytes release damage-associated molecular patterns (DAMPs) such as high mobility group box-1 (HMGB1), ATP, and DNA fragments
It is often studied in preclinical models linked with tissue response, tendon fibroblasts, gut pathways, and angiogenesis
Wang CC, Xu H, Man GCW, Zhang T, Chu KO, Chu CY, et al
Ricciardi MR, Tsao T, Abrams SL, Bergamo P, Steelman LS, Decandia S, Felicioni L, Ciuffreda L, Di Sanza C, Marchetti A, Cognetti F, McCubrey J, Konopleva M, Andreeff M , Tafuri A, Milella M
10.1016/j.fertnstert.2008.07.1781 62 HuangJ.OkukaM.McLeanM.KeefeD