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Most of the existing research comes from rodent studies
3.10 Traumatic brain injury and stroke Traumatic brain injury (TBI) and ischemic stroke are common acute central nervous system injuries that share a characteristic cascade: following the initial mechanical or perfusion insult, mitochondrial dysfunction ensues, leading to excessive reactive oxygen species (ROS) production, calcium overload, and neuronal apoptosis
Jorge Moreno, a Yale Medicine internist and assistant professor of medicine
The anabolic variety and redox status of GSH in the myocardium under pathological conditions When the heart is under stress from pathological factors, GSH redox homeostasis is disrupted, which is manifested by a significant decrease in GSH content and accumulation of GSSG in the myocardium